Vioxx
Drug Information
Physician
Prescribing Information |
Dosage & Administration
How VIOXX Is Supplied |
What is a Cox-II Inhibitor?
Physician
Prescribing Information
 VIOXX®
(rofecoxib tablets and oral suspension)
VIOXX (rofecoxib) is described chemically as 4-[4-(methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone.
It has the following chemical structure:
Rofecoxib
is a white to off-white to light yellow powder. It is sparingly soluble
in acetone, slightly soluble in methanol and isopropyl acetate, very
slightly soluble in ethanol, practically insoluble in octanol, and
insoluble in water. The empirical formula for rofecoxib is C17H14O4S,
and the molecular weight is 314.36
Each tablet of VIOXX for oral administration
contains either 12.5 mg, 25 mg, or 50 mg of rofecoxib and the following
inactive ingredients: croscarmellose sodium, hydroxypropyl cellulose,
lactose, magnesium stearate, microcrystalline cellulose, and yellow
ferric oxide. The 50 mg tablets also contain red ferric oxide.
Each 5 mL of the oral suspension contains
either 12.5 or 25 mg of rofecoxib and the following inactive ingredients:
citric acid (monohydrate), sodium citrate (dihydrate),
sorbitol solution, strawberry flavor, xanthan gum, and purified water.
Added as preservatives are sodium methylparaben 0.13% and
sodium propylparaben 0.02%. Learn
about VIOXX Drug from the FDA's web site Top of Page |
